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中英对照:给莫德纳疫苗正名

Let's correct the misconceptions about the Moderna vaccine
来源: 大中报 南茜(Nancy Jin)
 
 
出于对莫德纳疫苗的误解,大批的疫苗接种者离开莫德纳疫苗诊所,拒绝注射这款疫苗。虽然卫生机构极力阻止,疫苗接种者仍不断通过疫苗名声以及其有效性和安全性对各款疫苗进行比较,以人为标准将疫苗分等。辉瑞疫苗在加国,乃至全球疫苗评比赛中独具鳌头,而莫德纳疫苗却败给辉瑞屈居第二,在加国受到不公平待遇。
 
Vaccine recipients walked out of Moderna jab clinic in droves as misconception deemed the vaccine inferior to Pfizer. Although discouraged by health authorities, vaccine recipients constantly compare the available vaccines through their popularity, efficacy, and safety records. Pfizer beats all other jabs in Canada and around the world in the assumed vaccine hierarchy, and Moderna comes off the second-best, suffering unfair treatment in Canada.

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两剂辉瑞疫苗在临床试验中显示出95%的有效率,远远高于阿斯利康66.9%和强生60.3%的有效率。两剂辉瑞还为克制疫苗毒株变种的最佳利器,其针对Alpha 和最猖獗的Delta的有效率为92%和79%,比阿斯利康 分别高出19% and 9%。

Pfizer has the highest two-dose efficacy in clinical trials – around 95%, higher than 66.9% of J&J and 60.3% of AstraZeneca.   Two Pfizer doses also emerged as the most effective against variants-- with 92% and 79% effective against Alpha and the most dominant Delta variant --defeating AstraZeneca by 19% and 9% points respectively.
 
但辉瑞在这些竞赛中取得的所有奖杯都有莫德纳的一份儿。与辉瑞一样,莫德纳也有着无可厚非的安全纪录,与使阿斯利康和强生安全声誉受损的血栓反应毫不沾边。取得94%的临床有效性的莫德纳与辉瑞一起获得美国和加拿大监管部门的最先批准,并在两国大规模的疫苗运动开展之际,作为主导疫苗向接种者提供针剂。由于两种疫苗的高度相似性,NACI建议在施打二剂疫苗时可交互使用。

But Moderna has accompanied Pfizer in winning trophies in all the vaccines' efficacy and safety competitions. Moderna has enjoyed an equally stellar safety record as Pfizer, clearing off blood clotting cases that have tarnished AZ and J&J's safety reputation. With 94% efficacy in the clinical trial, it joined Pfizer in receiving the earliest regulatory approval in the US and Canada, dominating the mass vaccination campaigns in the two countries. Its striking resemblance to Pfizer has prompted NACI recommendations for their interchangeable use in the second dose vaccine rollout.

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莫德纳与辉瑞疫苗在现实世界中防止病毒传播和控制变异毒株泛滥蔓延方面起着至关重要的作用。随着45%的美国人口完全接种了疫苗莫德纳和辉瑞疫苗,新增感染率在6个月下降了94%。 在两种疫苗普及率极高的加拿大,疫情发生了奇迹般的逆转。辉瑞和莫德纳的卓越表现与一些效果较差、接种感染率极高的疫苗形成鲜明对比。在加拿大和美国疫情不断好转之际,世界上许多仍依赖二等疫苗的国家仍在遭受异毒株的肆虐,面临一轮轮的限制经济和生活的封城措施。
 
Both vaccines have played a dominant role in preventing the virus from spreading in the real world and stopping surging variant outbreaks.  With 45% of the US population fully vaccinated with Pfizer and Moderna, new cases have dropped 94% over six months. Reaching a remarkable vaccination rate in Canada using both vaccines, the country has miraculously recovered from the pandemic crisis. Pfizer and Moderna’s superior performance is in sharp contrast to the less effective vaccines with soaring breakthrough rates, creating unfortunate disparities in the global pandemic outcomes. As Canada and the US have quickly turned the pandemic around, many parts of the world using less effective vaccines continue to suffer new variant outbreaks, facing rolling lockdowns and restraining measures.  
 
辉瑞疫苗和莫德纳疫苗所使用的mRNA技术是两种疫苗获得异常成功的关键。mRNA包含制造刺突蛋白的基因指令,从而刺激免疫系统做出反应。与传统疫苗相比,mRNA疫苗所产生的机体免疫力更强,因为被疫苗激活的免疫系统会既产生抗体又制造免疫杀伤细胞,给病毒造成双重打击。同时,mRNA技术不存在利用病毒载体技术导致可能的严重血栓病症的病理机制,从而使辉瑞和莫德纳疫苗的接种者彻底避免了阿斯利康和强生疫苗可能出现的危及生命的疫苗恶性效应。
 
The advanced mRNA technology used in developing both Pfizer and Moderna vaccines has explained their stunning success. The messenger RNA contains genetic instructions to make spike proteins that will trigger the immune system's reaction. But compared to traditional vaccines, mRNA vaccines can generate a more powerful type of immunity, dealing a double strike at the virus by stimulating the immune system to make both antibodies and immune system killer cells.  Meanwhile, the mRNA technology does not provide the pathological mechanism that might have linked the viral vector vaccines of AZ and J&J to a severe blood clotting syndrome (VITT), allowing the mRNA recipients to avoid devastating and life-threatening adverse events altogether.
 
莫德纳是一家从未将药品推向市场的小型生化技术公司,这也许是人们看低莫德纳这款疫苗的原因所在。与世界顶级跨国制药商辉瑞相比,规模较小的莫德纳疫苗并未能像辉瑞疫苗那样在众星捧月中粉末登场,享受与辉瑞疫苗同等的镁光灯效应。尽管如此,莫德纳在抗击新冠疫情,解救全球于疫情灾难的战役中立下了并不比辉瑞丝毫逊色的战功。
 
Moderna is a small biotechnology company that has never brought a drug to market, may explain some misconception towards this amazingly successful vaccine. Compared to the multinational giant Pfizer, its smaller scale made the Moderna vaccine debut a much less famous fanfare than its equivalent counterpart. Nonetheless, Moderna has displayed an equally high caliber as Pfizer in fighting Covid 19 and saving the world from the ravaging pandemic.

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